1) Female Ferrets can die if they don't mate

If a female ferrets is in heat and she don't find a mate. She could be potentially die. When in heat, her body secrets high levels of estrogen and if this hormone stays in the blood for a prolonged period of a time, it can cause a progressive depression of bone marrow that results in a severe, life threatening aplastic anemia which is fatal.

    The female ferret does not have to get pregnant. She simply needs the act of mating. The physical act of mating induces ovulation for the female ferret and will bring her out of estrus. She'll then have a false pregnancy that will go full tern, (about 40 to 45 days), without actually giving birth.